The CLR and performance folks have told us old timers that some things never change 
, although if you read closely it does!
[A primer on setting base-addresses for managed DLLs] covers how for performance reasons you probably want to [NGen] your code (on the remote computer) and ensure you have your base-addresses setup to avoid clashes. The interesting thing is that with [ASLR] enabled on VISTA, Windows 7, Windows Server 2008 and higher it doesnt help .
So for the performance conscious .net coders out there targetting fast startups definitely have a read.
Gareth